AbbVie Announces New Data from its Dermatology Portfolio and Pipeline at the 28th European Academy of Dermatology and Venereology (EADV) Congress

Originally posted on Abbvie.com

– Twenty new abstracts underscore AbbVie’s commitment to advancing standards of care for people living with serious skin diseases
– Results from the LIMMitless trial evaluating continued safety and efficacy with SKYRIZI™ (risankizumab) in patients with moderate to severe plaque psoriasis at 2.5 years will be presented
– Safety and efficacy data up to 24 weeks will be presented from risankizumab Phase 2 investigational studies for the treatment of active psoriatic arthritis
– New data from a Phase 2b investigational study evaluating time to treatment response with upadacitinib for patients with atopic dermatitis

AbbVie, a research-based global biopharmaceutical company, today announced that it will present new results evaluating the safety and efficacy of SKYRIZI™ (risankizumab) at 2.5 years in adult patients with moderate to severe plaque psoriasis, as well as additional data on HUMIRA® (adalimumab) and the investigational JAK inhibitor upadacitinib, at the 28th European Academy of Dermatology and Venereology (EADV) Congress, October 9-13, in Madrid.

“Leveraging more than two decades of clinical experience with HUMIRA, AbbVie recently expanded its dermatology portfolio with the approval of SKYRIZI for patients living with moderate to severe plaque psoriasis,” said Marek Honczarenko, MD, PhD, vice president, global immunology development, AbbVie. “The new data presented at EADV will advance the knowledge around new and existing treatments for serious skin diseases, like psoriasis, as well as diseases with high levels of unmet need, such as atopic dermatitis and hidradenitis suppurativa.”

In addition to sharing new long-term data from the LIMMitless open-label extension study in moderate to severe plaque psoriasis, AbbVie will share results from its ongoing investigational Phase 2 program evaluating risankizumab for the treatment of psoriatic arthritis. Risankizumab is part of a collaboration between Boehringer Ingelheim and AbbVie, with AbbVie leading development and commercialization globally.

In addition, Phase 2b results evaluating time to treatment response with upadacitinib, an oral JAK inhibitor, under investigation for patients with moderate to severe atopic dermatitis will be shared as an oral presentation. Upadacitinib is not approved for atopic dermatitis by any regulatory authority, and its safety and efficacy have not been established in this indication.

Additional presentations include efficacy and safety results further evaluating HUMIRA in hidradenitis suppurativa.

“Chronic skin diseases can have a significant physical and psychosocial impact on patients,” said Jean-Marie Meurant, board president of the International Alliance of Dermatology Patient Organizations. “While progress has been made to improve the lives of patients, many still do not have access to the treatment and care they need and deserve. It’s critical that the scientific community build upon current research to better understand these diseases and continue to keep the patient experience at the forefront of their efforts.”

AbbVie Data at EADV

Risankizumab Abstracts
Psoriasis

  • Long-term Efficacy and Safety of Continuous Q12W Risankizumab: Results from the Open-Label Extension LIMMitless; Oral Presentation #FC01.01: Free Communications in Psoriasis; Thursday, 10 October 2019; 08:30 – 8:40 a.m. CEST
  • Direct Comparison of Risankizumab and Fumaric Acid Esters (FAEs) in Patients with Moderate to Severe Plaque Psoriasis Who Were Naive to Systemic Therapy; Oral ePoster #OP02.01: Inflammatory Skin Diseases; Friday, 11 October 2019; 10:15 – 10:25 a.m. CEST
  • Long-term Efficacy and Safety of Switching from Adalimumab to Risankizumab: Results from the Open-Label Extension LIMMitless; ePoster #P1713; Wednesday, 9 October 2019
  • Long-term Efficacy and Safety of Switching from Ustekinumab to Risankizumab: Results from the Open-Label Extension LIMMitless; ePoster #P1714; Wednesday, 9 October 2019
  • Impact of Body-Weight on the Efficacy and Exposure-Response of Risankizumab in Patients with Moderate to Severe Plaque Psoriasis: An Integrated Analysis of Two Phase 3 Clinical Trials; Oral Presentation #FC02.03: Free Communications in Psoriasis; Friday, 11 October 2019; 10:35 – 10:45 a.m. CEST
  • Safety of Risankizumab in Patients with Moderate to Severe Psoriasis: Analysis of Pooled Clinical Trial Data; ePoster #P1764; Wednesday, 9 October 2019
  • Comparison of Dermatology Quality of Life Index for Novel Treatments of Moderate to Severe Plaque Psoriasis: A Network Meta-Analysis; ePoster #P1716; Wednesday, 9 October 2019
  • Dose Escalation of Targeted Immunomodulator Treatment in Patients with Moderate to Severe Psoriasis; ePoster #P1791; Wednesday, 9 October 2019
  • Reasons for Drug Discontinuation Among Psoriasis Patients in the Corrona Psoriasis Registry; ePoster #P1796; Wednesday, 9 October 2019

Psoriatic arthritis

  • Efficacy and Safety of Risankizumab in Patients with Active Psoriatic Arthritis Over 24 Weeks: Clinical and Biomarker Results from a Phase 2 Trial; Oral Presentation #FC03.01: Free Communications in Therapy; Thursday, 10 October 2019; 1:15 – 1:25 p.m. CEST

Upadacitinib Abstracts
Atopic dermatitis

  • Time to Upadacitinib Treatment Response Over 16 Weeks for Patients with Atopic Dermatitis from a Phase 2b, Randomized, Placebo-Controlled Trial; Oral Presentation #FC07.06: Free Communications in Atopic Dermatitis; Saturday, 12 October 2019; 2:05 – 2:15 p.m. CEST
  • Eosinophil Count, Serum CCL17/18/26 and Immunoglobulin E Levels in Atopic Dermatitis: Upadacitinib Phase 2 Study Analysis; ePoster #P0272; Wednesday, 9 October 2019
  • Effects of Upadacitinib on Patient-Reported Symptoms and Impacts Due to Atopic Dermatitis: Post-Hoc Results from the Phase 2b Randomized, Placebo-Controlled Trial in Moderate-to-Severe Atopic Dermatitis; ePoster #P0255; Wednesday, 9 October 2019

HUMIRA Abstracts
Psoriasis

  • Long-term Real-World Safety and Effectiveness of Adalimumab for Moderate to Severe Psoriasis: 10-Year Interim Results from the ESPRIT Registry; Oral Presentation #FC01.02: Free Communications in Psoriasis; Thursday, 10 October 2019; 8:40 – 8:50 a.m. CEST
  • Real-World Treatment Effect of Adalimumab on Patient Reported Outcomes in Moderate-to-Severe Psoriasis – Results from the EQUIPE Study; ePoster #P1741; Wednesday, 9 October 2019

Hidradenitis suppurativa

  • Post Marketing Observational Study to Assess Quality of Life Changes in Swedish Patients with Moderate or Severe Hidradenitis Suppurativa after 6 Months on Adalimumab Treatment (HOPE study); ePoster #P0020; Wednesday, 9 October 2019
  • A Longitudinal Assessment of the Impact of Adalimumab on Work Productivity, Skin Pain, and Quality of Life Measures Among Patients with Hidradenitis Suppurativa; ePoster #P0005; Wednesday, 9 October 2019

Disease State Abstracts
Hidradenitis suppurativa

  • An Assessment of the Natural History of Hidradenitis Suppurativa: Results from the 2-Year Interim Analysis of an International, Prospective, Disease-based Registry (UNITE); Oral Presentation #FC08.05: Free Communications in Acne and Related Disorders; Saturday, 12 October 2019; 3:40 – 3:50 p.m. CEST
  • Correlation of Patient Demographic and Clinical Characteristics with Hidradenitis Suppurativa (HS) Symptom Assessment (HSSA) and Hidradenitis Suppurativa Impact Assessment (HSIA): Results from the UNITE Hidradenitis Suppurativa Disease Registry; Oral Presentation #FC08.03: Free Communications in Acne and Related Disorders; Saturday, 12 October 2019; 3:20 – 3:30 p.m. CEST
  • Baseline clinical characteristics from observational, multinational UNITE registry by disease severity using the International Hidradenitis Suppurativa Severity Score System (IHS4); Oral Presentation #FC08.02: Free Communications in Acne and Related Disorders; Friday, 11 October 2019; 10:35–10:45 a.m. CEST

About SKYRIZI™ (risankizumab) in the EU1

SKYRIZI (risankizumab) is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.